内容紹介
A Case of Stage Ⅳ Sigmoid Colon Cancer That Achieved Long-Term Survival with Oral Anticancer Drugs
Summary
An 80-year-old man presenting with abdominal distension was admitted to our hospital. He was diagnosed with sigmoid cancer with multiple liver and lung metastases. We first performed a sigmoidectomy to avoid obstruction, and then initiated chemotherapy with S-1(120 mg/day). The tumor showed a complete clinical response after 10 courses, but we had to change the regimen after 18 courses because of growth of the lung metastases. After 10 courses of capecitabine(4,200 mg/day)treatment, we again observed growth of the lung metastases; a new nodule, which was also considered to be a metastasis, appeared on the abdominal wall. We then decided to administer mFOLFOX6(5-fluorouracil+Leucovorin+oxaliplatin)after the patient had received oral anticancer drugs for 3 years 4 month. In conclusion, oral chemotherapy drugs may prevent tumor growth over a long period and improve quality of life(QOL)in elderly patients with Stage Ⅳ colon cancer.
要旨
症例は80歳,男性。腹部膨満感を主訴に当院を受診した。S状結腸癌多発肝転移・多発肺転移と診断され当科紹介となった。S状結腸切除術を施行後,S-1(120 mg/day)を10コース施行しclinical CRを得た。計18コース施行後に肺転移の増大を認めたためcapecitabine(4,200 mg/day)へ変更し10コース施行した。Stage Ⅳ結腸癌であったが,初診時より3年4か月間は経口抗癌剤のみで生存を得た。副作用の少ない経口抗癌剤は,Stage Ⅳ結腸癌の高齢者においても良好なQOLでの長期生存が期待できる。
目次
Summary
An 80-year-old man presenting with abdominal distension was admitted to our hospital. He was diagnosed with sigmoid cancer with multiple liver and lung metastases. We first performed a sigmoidectomy to avoid obstruction, and then initiated chemotherapy with S-1(120 mg/day). The tumor showed a complete clinical response after 10 courses, but we had to change the regimen after 18 courses because of growth of the lung metastases. After 10 courses of capecitabine(4,200 mg/day)treatment, we again observed growth of the lung metastases; a new nodule, which was also considered to be a metastasis, appeared on the abdominal wall. We then decided to administer mFOLFOX6(5-fluorouracil+Leucovorin+oxaliplatin)after the patient had received oral anticancer drugs for 3 years 4 month. In conclusion, oral chemotherapy drugs may prevent tumor growth over a long period and improve quality of life(QOL)in elderly patients with Stage Ⅳ colon cancer.
要旨
症例は80歳,男性。腹部膨満感を主訴に当院を受診した。S状結腸癌多発肝転移・多発肺転移と診断され当科紹介となった。S状結腸切除術を施行後,S-1(120 mg/day)を10コース施行しclinical CRを得た。計18コース施行後に肺転移の増大を認めたためcapecitabine(4,200 mg/day)へ変更し10コース施行した。Stage Ⅳ結腸癌であったが,初診時より3年4か月間は経口抗癌剤のみで生存を得た。副作用の少ない経口抗癌剤は,Stage Ⅳ結腸癌の高齢者においても良好なQOLでの長期生存が期待できる。