内容紹介
A Case of Recurrent Lung Cancer with Bone Metastases Treated with Tegafur-Uracil and Zoledronic Acid for Long-Term Survival
Summary
We present the case of an 84-year-old man with lumbago due to bone metastases from lung cancer that recurred three years after surgery. The patient received carboplatin-paclitaxel combination as first-line chemotherapy for the treatment of lung cancer, and palliative radiotherapy for the treatment of bone metastases. Gemcitabine was administered as second-line chemotherapy. However, disease progression was observed after three years, and he developed pulmonary metastases. The general condition of the patient worsened, and tegafur-uracil chemotherapy was initiated. Zoledronic acid was also administered. The tegafur-uracil treatment resulted in the disappearance of pulmonary metastases, and a stabilization of the bone metastases. Disease progression was observed after 6 years with a recurrence of pulmonary metastases; however, this did not have a negative impact on the patient's quality of life. Although slow progression may be inherent to lung cancers, it is also possible that the tegafur-uracil and zoledronic acid combination might have contributed to the patient's improved performance.
要旨
症例は84歳,男性。肺癌根治切除後3年後に腰椎への骨転移で再発し,carboplatinとpaclitaxelによる化学療法と骨転移に対し姑息的照射を行った。しかし,骨転移による疼痛の悪化と肺転移の出現を認めた。zoledronic acidとtegafur-uracil投与を行ったところ肺転移は著明に縮小し,骨転移巣も縮小,疼痛も緩和した。再発後6年経過し肺転移の新たな出現を認め,腰痛が再び悪化しているが生活の質は維持されている。肺癌自体の特性が関与している可能性があるが,二次治療以降で骨転移により患者の全身状態が不良な場合は,zoledronic acid投与に加えtegafur-uracilの投与が有効な場合もあると推察された。
目次
Summary
We present the case of an 84-year-old man with lumbago due to bone metastases from lung cancer that recurred three years after surgery. The patient received carboplatin-paclitaxel combination as first-line chemotherapy for the treatment of lung cancer, and palliative radiotherapy for the treatment of bone metastases. Gemcitabine was administered as second-line chemotherapy. However, disease progression was observed after three years, and he developed pulmonary metastases. The general condition of the patient worsened, and tegafur-uracil chemotherapy was initiated. Zoledronic acid was also administered. The tegafur-uracil treatment resulted in the disappearance of pulmonary metastases, and a stabilization of the bone metastases. Disease progression was observed after 6 years with a recurrence of pulmonary metastases; however, this did not have a negative impact on the patient's quality of life. Although slow progression may be inherent to lung cancers, it is also possible that the tegafur-uracil and zoledronic acid combination might have contributed to the patient's improved performance.
要旨
症例は84歳,男性。肺癌根治切除後3年後に腰椎への骨転移で再発し,carboplatinとpaclitaxelによる化学療法と骨転移に対し姑息的照射を行った。しかし,骨転移による疼痛の悪化と肺転移の出現を認めた。zoledronic acidとtegafur-uracil投与を行ったところ肺転移は著明に縮小し,骨転移巣も縮小,疼痛も緩和した。再発後6年経過し肺転移の新たな出現を認め,腰痛が再び悪化しているが生活の質は維持されている。肺癌自体の特性が関与している可能性があるが,二次治療以降で骨転移により患者の全身状態が不良な場合は,zoledronic acid投与に加えtegafur-uracilの投与が有効な場合もあると推察された。