内容紹介
A Case of Disseminated Carcinomatosis of the Bone Marrow with Disseminated Intravascular Coagulation Caused by Advanced Colon Cancer Successfully Treated with SOX/Bevacizumab
Summary
Our patient was a 58-year-old man who was diagnosed with a large bowel obstruction caused by ascending colon cancer, together with multiple liver metastases for which a right hemicolectomy was performed. After the operation, he developed disseminated intravascular coagulation(DIC)and severe anemia. Bone marrow biopsy findings led to a diagnosis of disseminated carcinomatosis of the bone marrow caused by colon cancer. We administered S-1+oxaliplatin(SOX) and bevacizumab(BV) chemotherapy, which improved the DIC. The patient was discharged from the hospital. After a total of six courses of chemotherapy, the carcinoma became resistant. We changed the drug regimen and his clinical condition improved. He survived for 292 days from the onset of disease.
要旨
症例は58歳,男性。多発肝転移を伴う上行結腸癌による大腸閉塞の診断で,結腸右半切除術を施行した。術後に著明な貧血と播種性血管内凝固症候群(disseminated intravascular coagulation: DIC)を合併し,骨髄穿刺の結果,大腸癌骨髄癌腫症と診断した。S-1+oxaliplatin(SOX)とbevacizumab(BV)を開始したところ改善し,退院することができた。6コースを施行し耐性となったがregimenを変更することで再び改善し,292日の生存が得られた。
目次
Summary
Our patient was a 58-year-old man who was diagnosed with a large bowel obstruction caused by ascending colon cancer, together with multiple liver metastases for which a right hemicolectomy was performed. After the operation, he developed disseminated intravascular coagulation(DIC)and severe anemia. Bone marrow biopsy findings led to a diagnosis of disseminated carcinomatosis of the bone marrow caused by colon cancer. We administered S-1+oxaliplatin(SOX) and bevacizumab(BV) chemotherapy, which improved the DIC. The patient was discharged from the hospital. After a total of six courses of chemotherapy, the carcinoma became resistant. We changed the drug regimen and his clinical condition improved. He survived for 292 days from the onset of disease.
要旨
症例は58歳,男性。多発肝転移を伴う上行結腸癌による大腸閉塞の診断で,結腸右半切除術を施行した。術後に著明な貧血と播種性血管内凝固症候群(disseminated intravascular coagulation: DIC)を合併し,骨髄穿刺の結果,大腸癌骨髄癌腫症と診断した。S-1+oxaliplatin(SOX)とbevacizumab(BV)を開始したところ改善し,退院することができた。6コースを施行し耐性となったがregimenを変更することで再び改善し,292日の生存が得られた。