内容紹介
Effect of Lidocaine Gargling on Taste Perception
Summary
Because stomatitis is a painful condition, gargling with lidocaine is often prescribed before meals. However, because lidocaine inhibits nerve conduction, lidocaine gargling may affect taste perception. Therefore, we studied the effects of lidocaine gargle on taste. We prepared samples of the 5 basic tastes at equivalent concentration levels in terms of the taste quotient. We conducted sensory tests to judge whether the samples could be tasted, and the threshold concentrations(50% taste rate)were estimated from the taste rates. The sensory test was repeated after the subjects gargled with lidocaine, and the efficacy ratio was calculated by comparing the threshold concentrations. Although no interaction was observed between the lidocaine gargle and the threshold concentration levels in the logistic regression analysis, significant differences were observed in the primary effects of each standard, such as the concentration levels, flavor, and bitterness. When the efficacy ratios based on the threshold values were calculated, increases in the thresholds for flavor and bitterness were observed. The results of this study suggested that gargling with lidocaine before a meal increases the thresholds for the appreciation of flavor and bitterness. This increase in the threshold values due to lidocaine was associated not with the pharmacological effect of the drug but with its strong bitterness.
要旨
口内炎は痛みを伴うため,リドカインうがい液が食事前に使用される。しかし,リドカインは神経の活動電位の伝導を抑制することから,味覚にも影響することが考えられる。そこで,うがい液が味覚に与える影響について検討を行った。5基本味について,味の上で等間隔となる濃度段階に調整した試料を作製した。試料が「味」を感じるか否かを判断する官能試験を行い,その判断率から閾値を推定した。リドカインうがい液でうがいをした後,同様の官能試験を行い,効力比を算定した。ロジスティック回帰分析を行うと,「うがい」と「濃度」の間に交互作用はみられなかったが,濃度,旨味,苦味の各水準の主効果において有意差がみられた。効力比を算定すると,旨味と苦味で閾値の上昇がみられた。リドカインによる閾値の上昇は薬理作用によるものではなく,リドカインの強い苦味の影響であることが考えられた。
目次
Summary
Because stomatitis is a painful condition, gargling with lidocaine is often prescribed before meals. However, because lidocaine inhibits nerve conduction, lidocaine gargling may affect taste perception. Therefore, we studied the effects of lidocaine gargle on taste. We prepared samples of the 5 basic tastes at equivalent concentration levels in terms of the taste quotient. We conducted sensory tests to judge whether the samples could be tasted, and the threshold concentrations(50% taste rate)were estimated from the taste rates. The sensory test was repeated after the subjects gargled with lidocaine, and the efficacy ratio was calculated by comparing the threshold concentrations. Although no interaction was observed between the lidocaine gargle and the threshold concentration levels in the logistic regression analysis, significant differences were observed in the primary effects of each standard, such as the concentration levels, flavor, and bitterness. When the efficacy ratios based on the threshold values were calculated, increases in the thresholds for flavor and bitterness were observed. The results of this study suggested that gargling with lidocaine before a meal increases the thresholds for the appreciation of flavor and bitterness. This increase in the threshold values due to lidocaine was associated not with the pharmacological effect of the drug but with its strong bitterness.
要旨
口内炎は痛みを伴うため,リドカインうがい液が食事前に使用される。しかし,リドカインは神経の活動電位の伝導を抑制することから,味覚にも影響することが考えられる。そこで,うがい液が味覚に与える影響について検討を行った。5基本味について,味の上で等間隔となる濃度段階に調整した試料を作製した。試料が「味」を感じるか否かを判断する官能試験を行い,その判断率から閾値を推定した。リドカインうがい液でうがいをした後,同様の官能試験を行い,効力比を算定した。ロジスティック回帰分析を行うと,「うがい」と「濃度」の間に交互作用はみられなかったが,濃度,旨味,苦味の各水準の主効果において有意差がみられた。効力比を算定すると,旨味と苦味で閾値の上昇がみられた。リドカインによる閾値の上昇は薬理作用によるものではなく,リドカインの強い苦味の影響であることが考えられた。