内容紹介
A Case of Thymic Cancer Effectively Treated by Weekly Paclitaxel Combined with Carboplatin
Summary
A 65-year-old woman with left chest pain, back pain, and palpitation that had persisted for 2 months was referred to our hospital. Computed tomography of her chest showed an anterior mediastinal tumor with mediastinal lymphadenopathy, left pleural effusion, and pericardial effusion. Endobronchial ultrasound-guided transbronchial needle aspiration of the subcarinal lymphadenopathy was performed. The pathological findings and other examinations such as bone scintigraphy suggested advanced thymic cancer(stageⅣb according to the Masaoka classification of thymic epithelial tumors). The patient was treated with combination chemotherapy of carboplatin(area under the curve[AUC]=6, 656 mg/body, day 1)and weekly paclitaxel(70 mg/m2, 100 mg/body, days 1, 8, and 15). After 4 cycles of chemotherapy, a partial response was achieved and the pericardial effusion disappeared. The patient did not experience any severe toxicity, except for grade 1 nausea, grade 2 anemia, and grade 2 alopecia. Weekly paclitaxel combined with carboplatin appears to be a useful regimen with minimal toxicity for advanced thymic cancer.
要旨 症例は65歳,女性。約2か月間続く左胸背部痛と動悸を主訴に前医を受診した。胸部CTで前縦隔腫瘤,縦隔リンパ節腫脹,左胸水,心嚢液貯留を認め,当院に紹介された。気管分岐下リンパ節に対する超音波気管支内視鏡下針生検および全身検索にて胸腺癌(正岡分類Ⅳb期)と診断した。carboplatin(CBDCA)+weekly paclitaxel(PTX)療法を4サイクル施行後,腫瘍は著明に縮小し,心嚢液減少,左胸水消失を認めた。grade 1の嘔気,grade 2の貧血と脱毛以外に重篤な副作用は認められなかった。毒性が少なく,かつ腫瘍縮小効果が得られる治療法として,CBDCA+weekly PTX療法は胸腺癌に対する有用な治療選択肢の一つと考えられた。
目次
Summary
A 65-year-old woman with left chest pain, back pain, and palpitation that had persisted for 2 months was referred to our hospital. Computed tomography of her chest showed an anterior mediastinal tumor with mediastinal lymphadenopathy, left pleural effusion, and pericardial effusion. Endobronchial ultrasound-guided transbronchial needle aspiration of the subcarinal lymphadenopathy was performed. The pathological findings and other examinations such as bone scintigraphy suggested advanced thymic cancer(stageⅣb according to the Masaoka classification of thymic epithelial tumors). The patient was treated with combination chemotherapy of carboplatin(area under the curve[AUC]=6, 656 mg/body, day 1)and weekly paclitaxel(70 mg/m2, 100 mg/body, days 1, 8, and 15). After 4 cycles of chemotherapy, a partial response was achieved and the pericardial effusion disappeared. The patient did not experience any severe toxicity, except for grade 1 nausea, grade 2 anemia, and grade 2 alopecia. Weekly paclitaxel combined with carboplatin appears to be a useful regimen with minimal toxicity for advanced thymic cancer.
要旨 症例は65歳,女性。約2か月間続く左胸背部痛と動悸を主訴に前医を受診した。胸部CTで前縦隔腫瘤,縦隔リンパ節腫脹,左胸水,心嚢液貯留を認め,当院に紹介された。気管分岐下リンパ節に対する超音波気管支内視鏡下針生検および全身検索にて胸腺癌(正岡分類Ⅳb期)と診断した。carboplatin(CBDCA)+weekly paclitaxel(PTX)療法を4サイクル施行後,腫瘍は著明に縮小し,心嚢液減少,左胸水消失を認めた。grade 1の嘔気,grade 2の貧血と脱毛以外に重篤な副作用は認められなかった。毒性が少なく,かつ腫瘍縮小効果が得られる治療法として,CBDCA+weekly PTX療法は胸腺癌に対する有用な治療選択肢の一つと考えられた。