内容紹介
Efficacy of Capecitabine/Cisplatin Chemotherapy after Failure of All Conventional Therapies in Patients with Advanced Gastric Cancer
Summary
There is no standard therapy for advanced gastric cancer patients who had already failed treatment with major anti-cancer drugs including fluoropyrimidine, cisplatin, taxans, and irinotecan. We report the results of treatment with capecitabine and cisplatin(XP)after the failure of all other conventional therapies. A total of five advanced gastric cancer patients were treated. The median age was 59 years(range, 46-76); there were 3 male and 2 female patients; performance status was 0/1/2: 2/2/1 patients, respectively. The median duration from start of first-line chemotherapy to XP was 653 days(range, 372-1,107). Three patients were treated after fourth-line therapy and two patients after fifth-line therapy. All of the patients had received S-1, cisplatin, irinotecan, paclitaxel, and docetaxel previously. Patients received 80 mg/m2 of cisplatin intravenously on day 1, and 1,000 mg/m2 of capecitabine orally twice a day from day 1 to day 14 followed by a 7-day rest period. Treatment courses were between 2 to 5. Median time to progression was 107 days. Median overall survival was 245 days. One PR and one SD were reported. All reported adverse events were manageable. XP is considered one of the effective regimens for advanced gastric cancer after all conventional therapies have failed.
要旨
主要薬剤を使い切った多次化学療法後の進行胃癌症例に対する治療には難渋する。多次化学療法後進行胃癌症例に対してXP療法を施行したので,その経験を報告する。症例は当センターで治療中の進行胃癌5例。59(46～76)歳。男性3例,女性2例。PSは0/1/2各2/2/1例。一次治療開始からXP療法までの期間は653(372～1,107)日で,四次治療後3例,五次治療後2例。全例ともS-1,CDDP,CPT-11,PTX,DOCの5剤は使用済であった。レジメンはカペシタビン2,000 mg/m2/day 2週投与1週休薬+CDDP 80 mg/m2/q3w。施行コース数は2～5コース。TTPは107日,MSTは245日であった。効果はPRとSDを各1例で得られた。有害事象は管理可能な範囲であった。XP療法は,多次化学療法後進行胃癌症例に対する治療の一つとして有用であると考えられた。
目次
Summary
There is no standard therapy for advanced gastric cancer patients who had already failed treatment with major anti-cancer drugs including fluoropyrimidine, cisplatin, taxans, and irinotecan. We report the results of treatment with capecitabine and cisplatin(XP)after the failure of all other conventional therapies. A total of five advanced gastric cancer patients were treated. The median age was 59 years(range, 46-76); there were 3 male and 2 female patients; performance status was 0/1/2: 2/2/1 patients, respectively. The median duration from start of first-line chemotherapy to XP was 653 days(range, 372-1,107). Three patients were treated after fourth-line therapy and two patients after fifth-line therapy. All of the patients had received S-1, cisplatin, irinotecan, paclitaxel, and docetaxel previously. Patients received 80 mg/m2 of cisplatin intravenously on day 1, and 1,000 mg/m2 of capecitabine orally twice a day from day 1 to day 14 followed by a 7-day rest period. Treatment courses were between 2 to 5. Median time to progression was 107 days. Median overall survival was 245 days. One PR and one SD were reported. All reported adverse events were manageable. XP is considered one of the effective regimens for advanced gastric cancer after all conventional therapies have failed.
要旨
主要薬剤を使い切った多次化学療法後の進行胃癌症例に対する治療には難渋する。多次化学療法後進行胃癌症例に対してXP療法を施行したので,その経験を報告する。症例は当センターで治療中の進行胃癌5例。59(46～76)歳。男性3例,女性2例。PSは0/1/2各2/2/1例。一次治療開始からXP療法までの期間は653(372～1,107)日で,四次治療後3例,五次治療後2例。全例ともS-1,CDDP,CPT-11,PTX,DOCの5剤は使用済であった。レジメンはカペシタビン2,000 mg/m2/day 2週投与1週休薬+CDDP 80 mg/m2/q3w。施行コース数は2～5コース。TTPは107日,MSTは245日であった。効果はPRとSDを各1例で得られた。有害事象は管理可能な範囲であった。XP療法は,多次化学療法後進行胃癌症例に対する治療の一つとして有用であると考えられた。