内容紹介
A Case of Progressive Gastric Carcinoma Accompanied by Disseminated Carcinomatosis of Bone Marrow(DCBM)Due to Bone Metastasis, with DIC Recovery by Administration of S-1 and Docetaxel
Summary
A 63-year-old- female was admitted to our hospital complaining of cough. Based on CT, bone centigram and peripheral blood findings, a diagnosis of gastric carcinoma accompanied by bone marrow metastasis was made. As DIC developed following hospital admission, S-1 and docetaxel(DOC)therapy was initiated(daily oral administration of 80 mg/m2 S-1 for 14 days and DOC at 40 mg/m2 on day 1, q3w). Recovery from DIC was achieved. S-1 and DOC therapy is considered to be effective for DIC due to bone marrow metastasis of gastric carcinoma. S-1/DOC is thought to be an effective chemotherapy against progressive gastric carcinoma accompanied by disseminated carcinomatosis bone marrow with DIC.
要旨
症例は63歳,女性。咳嗽を主訴に来院した。癌性リンパ管症を合併した胃癌,播種性骨髄癌症と診断した。入院後,DICを合併したが,S-1/docetaxel(DOC)併用療法(S-1 80 mg/m2 2週間投与1週休薬,DOC 40 mg/m2 day 1,3週ごと)を施行しDICから離脱。4コース施行後,呼吸困難感,全身状態の改善を得て退院し,外来化学療法に移行ができた。S-1/DOC併用療法は胃癌,播種性骨髄症によるDICに対し有効な治療法の選択肢と考えられる。
目次
Summary
A 63-year-old- female was admitted to our hospital complaining of cough. Based on CT, bone centigram and peripheral blood findings, a diagnosis of gastric carcinoma accompanied by bone marrow metastasis was made. As DIC developed following hospital admission, S-1 and docetaxel(DOC)therapy was initiated(daily oral administration of 80 mg/m2 S-1 for 14 days and DOC at 40 mg/m2 on day 1, q3w). Recovery from DIC was achieved. S-1 and DOC therapy is considered to be effective for DIC due to bone marrow metastasis of gastric carcinoma. S-1/DOC is thought to be an effective chemotherapy against progressive gastric carcinoma accompanied by disseminated carcinomatosis bone marrow with DIC.
要旨
症例は63歳,女性。咳嗽を主訴に来院した。癌性リンパ管症を合併した胃癌,播種性骨髄癌症と診断した。入院後,DICを合併したが,S-1/docetaxel(DOC)併用療法(S-1 80 mg/m2 2週間投与1週休薬,DOC 40 mg/m2 day 1,3週ごと)を施行しDICから離脱。4コース施行後,呼吸困難感,全身状態の改善を得て退院し,外来化学療法に移行ができた。S-1/DOC併用療法は胃癌,播種性骨髄症によるDICに対し有効な治療法の選択肢と考えられる。