内容紹介
Treatable and Untreatable Forms of Recurrent Prostate Cancer
Summary
The incidence of prostate cancer in the Japanese population has increased because of the increase in life expectancy, consumption of westernized diets, and improvements in prostate cancer screening by using the prostate-specific antigen(PSA)test. Further, in the past 10 years, there have been great advancements in the treatment options available for prostate cancer. Radical treatment methods, such as robot-assisted surgery, intensity-modulated radiation therapy, and particle beam radiation therapy, may have anticancer effects and may improve the quality of life by preserving micturition ability and sexual function. Radiotherapy and endocrine therapy have been shown to prevent postoperative recurrence. Endocrine therapy has been demonstrated to be effective in preventing recurrence after radiotherapy. Moreover, endocrine therapy can be administered to patients at all stages of prostate cancer and is often used as the initial treatment for advanced prostate cancer, particularly in patients with metastasis. However, recurrence(relapse)after endocrine therapy is associated with a poor prognosis. In this study, we describe all the available treatment options for prostate cancer and the treatable and untreatable forms of recurrent prostate cancer.
要旨
平均寿命の延長,食事の欧米化,前立腺特異抗原(PSA)検診の普及により,わが国の前立腺癌の罹患数は近年増加している。一方,この10年で前立腺癌の治療法は大きく進展した。根治療法としてロボット支援手術や強度変調放射線治療,粒子線治療により,制癌効果のみならず排尿や性機能の回復などのQOLも良好とされる。手術後の再発では放射線治療やホルモン療法,放射線治療後の再発ではホルモン療法を行うことで一定の治療効果が得られている。ホルモン療法はすべての病期に適用可能であり,特に転移を有する進行癌の初回治療として用いられることが多い。しかしながら,ホルモン療法後の再発(再燃)は予後不良である。本稿では,前立腺癌の現在の治療法や治療における前立腺癌で治せる再発癌・治せない再発癌について述べる。
目次
Summary
The incidence of prostate cancer in the Japanese population has increased because of the increase in life expectancy, consumption of westernized diets, and improvements in prostate cancer screening by using the prostate-specific antigen(PSA)test. Further, in the past 10 years, there have been great advancements in the treatment options available for prostate cancer. Radical treatment methods, such as robot-assisted surgery, intensity-modulated radiation therapy, and particle beam radiation therapy, may have anticancer effects and may improve the quality of life by preserving micturition ability and sexual function. Radiotherapy and endocrine therapy have been shown to prevent postoperative recurrence. Endocrine therapy has been demonstrated to be effective in preventing recurrence after radiotherapy. Moreover, endocrine therapy can be administered to patients at all stages of prostate cancer and is often used as the initial treatment for advanced prostate cancer, particularly in patients with metastasis. However, recurrence(relapse)after endocrine therapy is associated with a poor prognosis. In this study, we describe all the available treatment options for prostate cancer and the treatable and untreatable forms of recurrent prostate cancer.
要旨
平均寿命の延長,食事の欧米化,前立腺特異抗原(PSA)検診の普及により,わが国の前立腺癌の罹患数は近年増加している。一方,この10年で前立腺癌の治療法は大きく進展した。根治療法としてロボット支援手術や強度変調放射線治療,粒子線治療により,制癌効果のみならず排尿や性機能の回復などのQOLも良好とされる。手術後の再発では放射線治療やホルモン療法,放射線治療後の再発ではホルモン療法を行うことで一定の治療効果が得られている。ホルモン療法はすべての病期に適用可能であり,特に転移を有する進行癌の初回治療として用いられることが多い。しかしながら,ホルモン療法後の再発(再燃)は予後不良である。本稿では,前立腺癌の現在の治療法や治療における前立腺癌で治せる再発癌・治せない再発癌について述べる。