内容紹介
A Case of Mucinous Adenocarcinoma of the Sigmoid Colon with Disseminated Carcinomatosis of the Bone Marrow Successfully Treated with FOLFOX4/Bevacizumab
Summary
A 68-year-old man complaining of back pain was given the diagnosis of mucinous adenocarcinoma of the sigmoid colon with disseminated carcinomatosis of bone marrow and disseminated intravascular coagulation(DIC). We started chemotherapy using FOLFOX4. After we confirmed that DIC had improved following 2 courses of FOLFOX4, bevacizumab was added to FOLFOX4. Laboratory studies revealed a serum CEA level of 11,432 ng/mL, which improved to 245 ng/mL after a total of 9 courses of chemotherapy. Chemotherapy is continuing as scheduled at 6 months from the onset of this disease.
要旨
症例は68歳,男性。腰背部痛の精査で播種性骨髄癌腫症を伴うS状結腸粘液癌と診断した。disseminated intravascular coagulation syndrome(DIC)を併発し,DIC治療と並行してFOLFOX4の投与を2コース施行。DICの改善を確認し,bevacizumabを追加併用して治療を継続した。治療前CEA 11,432 ng/mLであったが,計9コース施行後CEA 245 ng/mLまで低下し,QOLも改善した。現在発症後6か月の経過であるが治療継続中である。
目次
Summary
A 68-year-old man complaining of back pain was given the diagnosis of mucinous adenocarcinoma of the sigmoid colon with disseminated carcinomatosis of bone marrow and disseminated intravascular coagulation(DIC). We started chemotherapy using FOLFOX4. After we confirmed that DIC had improved following 2 courses of FOLFOX4, bevacizumab was added to FOLFOX4. Laboratory studies revealed a serum CEA level of 11,432 ng/mL, which improved to 245 ng/mL after a total of 9 courses of chemotherapy. Chemotherapy is continuing as scheduled at 6 months from the onset of this disease.
要旨
症例は68歳,男性。腰背部痛の精査で播種性骨髄癌腫症を伴うS状結腸粘液癌と診断した。disseminated intravascular coagulation syndrome(DIC)を併発し,DIC治療と並行してFOLFOX4の投与を2コース施行。DICの改善を確認し,bevacizumabを追加併用して治療を継続した。治療前CEA 11,432 ng/mLであったが,計9コース施行後CEA 245 ng/mLまで低下し,QOLも改善した。現在発症後6か月の経過であるが治療継続中である。