内容紹介
A Case of Esophageal Cancer with Septic Disseminated Intravascular Coagulation Treated with Recombinant Human Soluble Thrombomodulin during Chemoradiation Therapy
Summary
A 70-year-old woman was diagnosed with synchronous advanced esophageal cancer and early renal cancer. During chemo-radiation therapy for the esophageal cancer, she suffered from septic shock due to pneumonia. She got worse despite the administration of antibiotics and γglobulin. On the following day, she was diagnosed with septic disseminated intravascular coagulation(DIC)on the basis of the diagnostic criterion for acute DIC. Recombinant human soluble thrombomodulin(rTM)was administered to treat the DIC. The patient responded promptly to rTM treatment and recovered from the DIC in just 1 day. rTM is thought to be an effective drug for sepsis-induced DIC during chemoradiation therapy.
要旨
症例は70歳,女性。転移性骨腫瘍を伴う進行食道癌と早期左腎癌の同時性重複癌と診断された。食道癌に対する化学放射線治療中に肺炎による敗血症性ショックを発症し,抗生剤とγグロブリン製剤による治療を開始した。病状は悪化し,急性期DIC診断基準に従ってDICと診断した。DIC治療として,組換えヒト可溶型トロンボモジュリン(rTM)の投与を開始したところ,翌日には臨床症状と検査結果が改善しDICを早期に離脱した。化学放射線治療中の敗血症性DICにrTMが有効であった。
目次
Summary
A 70-year-old woman was diagnosed with synchronous advanced esophageal cancer and early renal cancer. During chemo-radiation therapy for the esophageal cancer, she suffered from septic shock due to pneumonia. She got worse despite the administration of antibiotics and γglobulin. On the following day, she was diagnosed with septic disseminated intravascular coagulation(DIC)on the basis of the diagnostic criterion for acute DIC. Recombinant human soluble thrombomodulin(rTM)was administered to treat the DIC. The patient responded promptly to rTM treatment and recovered from the DIC in just 1 day. rTM is thought to be an effective drug for sepsis-induced DIC during chemoradiation therapy.
要旨
症例は70歳,女性。転移性骨腫瘍を伴う進行食道癌と早期左腎癌の同時性重複癌と診断された。食道癌に対する化学放射線治療中に肺炎による敗血症性ショックを発症し,抗生剤とγグロブリン製剤による治療を開始した。病状は悪化し,急性期DIC診断基準に従ってDICと診断した。DIC治療として,組換えヒト可溶型トロンボモジュリン(rTM)の投与を開始したところ,翌日には臨床症状と検査結果が改善しDICを早期に離脱した。化学放射線治療中の敗血症性DICにrTMが有効であった。