内容紹介
A Case of Liver Metastasis of Primary Duodenal Cancer Effectively Treated with Docetaxel Therapy
Summary
A 75-year-old man who complained of upper abdominal discomfort was diagnosed with primary duodenal cancer. The patient was treated with a pancreaticoduodenectomy, ascending colectomy and postoperative chemotherapy of S-1 and irinotecan[IRIS; S-1, 80 mg/m2(days 1-14); irinotecan, 100 mg/m2(days 1 and 15, every 4 weeks)]. However, after 4 IRIS cycles, computed tomography revealed a liver metastasis and massive ascites. The patient received second-line chemotherapy of tri-weekly docetaxel[60 mg/m2,(day 1, every 3 weeks)]. After 2 cycles of docetaxel therapy, the liver tumor and ascites became undetectable. The patient was doing well 13 months after the operation. Key words: Primary duodenal cancer, Chemotherapy, Docetaxel(Received Sep. 13, 2012/Accepted Mar. 21, 2013)
要旨 症例は75歳,男性。上腹部不快感を主訴とし,上部消化管内視鏡検査で原発性十二指腸癌と診断された。上行結腸合併切除を伴う膵頭部十二指腸切除術を施行した。病理診断は高分化腺癌で,膵切除断端陽性であったため,術後化学療法を行った。S-1/CDDP療法を検討したが,腎機能障害が疑われたためS-1/CPT-11併用(IRIS)療法とした。4コース投与後に肝転移と腹水が出現し,docetaxel療法へ変更した。変更後,2コースで肝転移と腹水が消失した。術後13か月を経過し,現在外来通院中である。
目次
Summary
A 75-year-old man who complained of upper abdominal discomfort was diagnosed with primary duodenal cancer. The patient was treated with a pancreaticoduodenectomy, ascending colectomy and postoperative chemotherapy of S-1 and irinotecan[IRIS; S-1, 80 mg/m2(days 1-14); irinotecan, 100 mg/m2(days 1 and 15, every 4 weeks)]. However, after 4 IRIS cycles, computed tomography revealed a liver metastasis and massive ascites. The patient received second-line chemotherapy of tri-weekly docetaxel[60 mg/m2,(day 1, every 3 weeks)]. After 2 cycles of docetaxel therapy, the liver tumor and ascites became undetectable. The patient was doing well 13 months after the operation. Key words: Primary duodenal cancer, Chemotherapy, Docetaxel(Received Sep. 13, 2012/Accepted Mar. 21, 2013)
要旨 症例は75歳,男性。上腹部不快感を主訴とし,上部消化管内視鏡検査で原発性十二指腸癌と診断された。上行結腸合併切除を伴う膵頭部十二指腸切除術を施行した。病理診断は高分化腺癌で,膵切除断端陽性であったため,術後化学療法を行った。S-1/CDDP療法を検討したが,腎機能障害が疑われたためS-1/CPT-11併用(IRIS)療法とした。4コース投与後に肝転移と腹水が出現し,docetaxel療法へ変更した。変更後,2コースで肝転移と腹水が消失した。術後13か月を経過し,現在外来通院中である。