内容紹介
Complete Remission after Weekly Intravenous Nanoparticle Albumin-Bound Paclitaxel in Elderly Patients with Non-Small-Cell Lung Cancer
Summary
Case 1: An 86-year-old man was diagnosed with large cell or squamous cell lung cancer of clinical StageⅡA. He was administered nanoparticle albumin-bound paclitaxel(nab-PTX)as fourth-line chemotherapy after monochemotherapy with docetaxel, vinorelbine, and S-1. The patient continues to show complete remission at the 15 courses of nab-PTX. Case 2: A 79-year-old man underwent partial resection of the right lower lung, and the pathological diagnosis was large cell lung cancer of pStageⅠA. However, recurrence in the right lung and multiple lymph node metastases were identified 3 years after the surgery. He was administered nab-PTX as second-line chemotherapy after vinorelbine monotherapy, and he has shown complete remission for a year. Weekly intravenous nab-PTX may be useful in elderly patients with non-small-cell lung cancer.
要旨
症例1: 86歳,男性。気管支鏡による擦過細胞診で扁平上皮癌もしくは大細胞癌が示唆され,cStageⅡAと診断された。docetaxel単剤,vinorelbine(VNR)単剤,S-1内服を行い,partial response(PR)を得られた。その後,nanoparticle albumin-bound paclitaxel(nab-PTX)を用いて4コース目でcomplete remission(CR),計15コース投与しCRを維持できている。症例2: 79歳,男性。右肺下葉部分切除術施行,病理診断は大細胞癌,pStageⅠAであった。3年後,肺内転移,多発リンパ節転移を認め,83歳からVNR単剤による治療を4コース行い,PRであった。血管炎のためnab-PTXに変更した。3コース施行後CR,その後も計12コース投与しCRを維持できている。高齢者非小細胞肺癌の二次治療以降で,nab-PTX単剤治療は有力な選択肢の一つになり得る。
目次
Summary
Case 1: An 86-year-old man was diagnosed with large cell or squamous cell lung cancer of clinical StageⅡA. He was administered nanoparticle albumin-bound paclitaxel(nab-PTX)as fourth-line chemotherapy after monochemotherapy with docetaxel, vinorelbine, and S-1. The patient continues to show complete remission at the 15 courses of nab-PTX. Case 2: A 79-year-old man underwent partial resection of the right lower lung, and the pathological diagnosis was large cell lung cancer of pStageⅠA. However, recurrence in the right lung and multiple lymph node metastases were identified 3 years after the surgery. He was administered nab-PTX as second-line chemotherapy after vinorelbine monotherapy, and he has shown complete remission for a year. Weekly intravenous nab-PTX may be useful in elderly patients with non-small-cell lung cancer.
要旨
症例1: 86歳,男性。気管支鏡による擦過細胞診で扁平上皮癌もしくは大細胞癌が示唆され,cStageⅡAと診断された。docetaxel単剤,vinorelbine(VNR)単剤,S-1内服を行い,partial response(PR)を得られた。その後,nanoparticle albumin-bound paclitaxel(nab-PTX)を用いて4コース目でcomplete remission(CR),計15コース投与しCRを維持できている。症例2: 79歳,男性。右肺下葉部分切除術施行,病理診断は大細胞癌,pStageⅠAであった。3年後,肺内転移,多発リンパ節転移を認め,83歳からVNR単剤による治療を4コース行い,PRであった。血管炎のためnab-PTXに変更した。3コース施行後CR,その後も計12コース投与しCRを維持できている。高齢者非小細胞肺癌の二次治療以降で,nab-PTX単剤治療は有力な選択肢の一つになり得る。