内容紹介
A Case of Severe Bradycardia Induced by Combination Chemotherapy with Cisplatin and 5-Fluorouracil
Summary
A 78-year-old man with Stage Ⅲ esophageal cancer was referred to our hospital. Combination chemotherapy with cisplatin(CDDP)and 5-fluorouracil(5-FU)was initiated. The patient experienced bradycardia episodes after starting the cisplatin infusion on day 1; he was otherwise asymptomatic. Therefore, combination chemotherapy was continued. However, on day 4, his heart rate dropped to 22 beats/min, with no other symptoms; however, treatment was stopped. After treatment was stopped, the patient's heart rate improved gradually and returned to normal in a few days. Combination chemotherapy with CDDP and 5-FU is a useful treatment for esophageal cancer, but it may induce severe bradycardia. Therefore, we must perform infusion therapy with caution.
要旨
症例は78歳,男性。食物の通過不良を主訴に近医受診し,食道癌を指摘され紹介。精査にてStage Ⅲの食道癌と診断し,術前5-fluorouracil(5-FU)+cisplatin(CDDP)(FP療法)を施行した。第1日目のCDDP投与開始とともに徐脈を認めたが自覚症状はなく,治療を継続した。第4日目に自覚症状は伴わないが高度徐脈を認めたため化学療法を中止し,その後徐脈は軽快した。FP療法は食道癌に対する有用な治療であるが,高度徐脈を合併する可能性もあり注意する必要がある。
目次
Summary
A 78-year-old man with Stage Ⅲ esophageal cancer was referred to our hospital. Combination chemotherapy with cisplatin(CDDP)and 5-fluorouracil(5-FU)was initiated. The patient experienced bradycardia episodes after starting the cisplatin infusion on day 1; he was otherwise asymptomatic. Therefore, combination chemotherapy was continued. However, on day 4, his heart rate dropped to 22 beats/min, with no other symptoms; however, treatment was stopped. After treatment was stopped, the patient's heart rate improved gradually and returned to normal in a few days. Combination chemotherapy with CDDP and 5-FU is a useful treatment for esophageal cancer, but it may induce severe bradycardia. Therefore, we must perform infusion therapy with caution.
要旨
症例は78歳,男性。食物の通過不良を主訴に近医受診し,食道癌を指摘され紹介。精査にてStage Ⅲの食道癌と診断し,術前5-fluorouracil(5-FU)+cisplatin(CDDP)(FP療法)を施行した。第1日目のCDDP投与開始とともに徐脈を認めたが自覚症状はなく,治療を継続した。第4日目に自覚症状は伴わないが高度徐脈を認めたため化学療法を中止し,その後徐脈は軽快した。FP療法は食道癌に対する有用な治療であるが,高度徐脈を合併する可能性もあり注意する必要がある。