内容紹介
Enhancement of Cytotoxic T Lymphocytes(CTLs)Infiltration into the Cancer Tissues
Summary
Recently, with the rapid development of elucidating the tumor immunological status, it has become clear that various lymphocytes, which are infiltrating tumor, are deeply involved in not only tumor growth but also its elimination. The interest and importance of cytotoxic T cells(CTLs)for cancer immunotherapy has been further increased, since CTLs play an important role in eliminating cancer cells by having high cytotoxic activity and high proliferation ability. To achieve potent anti-tumor effects, in addition to the anti-tumor immune response induced by various methods such as cancer peptide vaccine and immune checkpoint inhibitor, it is thought to be essential that CTLs should migrate and invade into localized cancer tissues. In this article, we will introduce the latest immunotherapies related to CTLs infiltration, and various methods to enhancement of CTLs infiltration into the cancer tissues.
要旨
近年,がん組織の微小環境の解明が著しく進んだ結果,がんに浸潤している様々な細胞が腫瘍の増殖や排除に深く関与していることが明らかとなってきた。そのなかでも,がんの排除に直接作用する細胞傷害性T細胞(CTL)は,高い細胞傷害活性と増殖能をもち,がん免疫療法において重要な役割をもつ細胞として,よりいっそう注目を集めている。がんペプチドワクチンをはじめとする様々な手段による免疫誘導や,免疫チェックポイント阻害抗体による抑制解除においても,強力な抗腫瘍効果を得るためにはCTLのがん局所への移行,浸潤が必要不可欠である。本稿では,がん局所へのCTL浸潤の増強のための工夫とそれらを応用した最新のがん免疫療法について紹介する。
目次
Summary
Recently, with the rapid development of elucidating the tumor immunological status, it has become clear that various lymphocytes, which are infiltrating tumor, are deeply involved in not only tumor growth but also its elimination. The interest and importance of cytotoxic T cells(CTLs)for cancer immunotherapy has been further increased, since CTLs play an important role in eliminating cancer cells by having high cytotoxic activity and high proliferation ability. To achieve potent anti-tumor effects, in addition to the anti-tumor immune response induced by various methods such as cancer peptide vaccine and immune checkpoint inhibitor, it is thought to be essential that CTLs should migrate and invade into localized cancer tissues. In this article, we will introduce the latest immunotherapies related to CTLs infiltration, and various methods to enhancement of CTLs infiltration into the cancer tissues.
要旨
近年,がん組織の微小環境の解明が著しく進んだ結果,がんに浸潤している様々な細胞が腫瘍の増殖や排除に深く関与していることが明らかとなってきた。そのなかでも,がんの排除に直接作用する細胞傷害性T細胞(CTL)は,高い細胞傷害活性と増殖能をもち,がん免疫療法において重要な役割をもつ細胞として,よりいっそう注目を集めている。がんペプチドワクチンをはじめとする様々な手段による免疫誘導や,免疫チェックポイント阻害抗体による抑制解除においても,強力な抗腫瘍効果を得るためにはCTLのがん局所への移行,浸潤が必要不可欠である。本稿では,がん局所へのCTL浸潤の増強のための工夫とそれらを応用した最新のがん免疫療法について紹介する。