内容紹介
A Case of Relapsed Colon Cancer Successfully Treated by Capecitabine
Summary
We report a case of advanced relapsed colon cancer, which had multiple liver and spleen metastasis, controlled for about two years by capecitabine therapy. A 60-year-old female had been diagnosed with ileus due to sigmoid colon cancer in August, 2005. She received sigmoidectomy and adjuvant chemotherapy(Leucovorin/5-fluorouracil therapy). In postoperative observation, multiple liver and spleen metastasis were detected by computed tomography in February, 2008. Therefore, she was administered twenty courses of FOLFOX therapy. However, a peripheral nerve disturbance appeared. There fore chemotherapy was changed from FOLFOX therapy to FOLFIRI therapy. After 2 courses of FOLFIRI therapy, she had severe nausea, vomiting, appetite loss and diarrhea. Therefore, chemotherapy was changed from FOLFIRI therapy to capecitabine therapy. After capecitabine therapy, her multiple liver and spleen metastasis disappeared, and complete response has continued for about 2 years. She has remained on capecitabine therapy and has a good quality of life.
要旨
今回S状結腸癌術後多発肝転移,多発脾転移を認めた症例に対し,capecitabine療法を施行したところ約2年間にわたりcomplete response(CR)を維持している症例を経験したため報告した。症例は60代,女性。2005年8月,S状結腸癌に対しS状結腸切除術を施行した後,Leucovorin/5-fluorouracil(LV/5-FU)療法を術後補助療法として2コース施行した。2008年2月,経過観察CTにて多発肝転移,多発脾転移を認めた。そのためFOLFOX療法を20コース施行。末梢神経障害を認めたため,FOLFIRI療法に変更した。FOLFIRI療法を2コース施行したが著明な吐気,嘔吐,食欲不振にて中止した。その後capecitabine療法を施行し経過観察したところ,CT所見上多発肝転移および多発脾転移の消失を認めCRと判断された。以後2年間にわたりCRを維持している。
目次
Summary
We report a case of advanced relapsed colon cancer, which had multiple liver and spleen metastasis, controlled for about two years by capecitabine therapy. A 60-year-old female had been diagnosed with ileus due to sigmoid colon cancer in August, 2005. She received sigmoidectomy and adjuvant chemotherapy(Leucovorin/5-fluorouracil therapy). In postoperative observation, multiple liver and spleen metastasis were detected by computed tomography in February, 2008. Therefore, she was administered twenty courses of FOLFOX therapy. However, a peripheral nerve disturbance appeared. There fore chemotherapy was changed from FOLFOX therapy to FOLFIRI therapy. After 2 courses of FOLFIRI therapy, she had severe nausea, vomiting, appetite loss and diarrhea. Therefore, chemotherapy was changed from FOLFIRI therapy to capecitabine therapy. After capecitabine therapy, her multiple liver and spleen metastasis disappeared, and complete response has continued for about 2 years. She has remained on capecitabine therapy and has a good quality of life.
要旨
今回S状結腸癌術後多発肝転移,多発脾転移を認めた症例に対し,capecitabine療法を施行したところ約2年間にわたりcomplete response(CR)を維持している症例を経験したため報告した。症例は60代,女性。2005年8月,S状結腸癌に対しS状結腸切除術を施行した後,Leucovorin/5-fluorouracil(LV/5-FU)療法を術後補助療法として2コース施行した。2008年2月,経過観察CTにて多発肝転移,多発脾転移を認めた。そのためFOLFOX療法を20コース施行。末梢神経障害を認めたため,FOLFIRI療法に変更した。FOLFIRI療法を2コース施行したが著明な吐気,嘔吐,食欲不振にて中止した。その後capecitabine療法を施行し経過観察したところ,CT所見上多発肝転移および多発脾転移の消失を認めCRと判断された。以後2年間にわたりCRを維持している。