内容紹介
Preventive Trial of Preheating Administration of Oxaliplatin-Diluted Solution in Combination with a Hot Compress for Oxaliplatin-Induced Venous Pain
Summary
Venous pain induced by oxaliplatin(L-OHP)is a clinical problem in relation to adherence in the CapeOX regimen. We investigated the preventive effect of nursing care preheating administration of L-OHP a hot compress for colorectal cancer patients who received L-OHP via the peripheral venous route between January 2010 and January 2011. L-OHP was diluted in 500 mL of 5% glucose and administered by 2 hours. We evaluated a total of 64 courses among fifteen patients. The presence of any symptoms, any pain with or without touch, and some symptoms of numbness at the L-OHP-administered arm were defined as phlebitis, venous pain, and acute peripheral neuropathy, respectively. The prevalence of phlebitis, venous pain, and acute peripheral neuropathy in the nursing care group was 56.5%, 32.6%, and 25.8%, respectively, which was not significantly less in comparison with the control group(72.2%, 38.9%, and 54.5%, respectively). These results suggest that both types of nursing care, preheating administration and a hot compress, may be effective for the relief of acute peripheral neuropathy induced by L-OHP.
要旨
実地臨床では,CapeOXにおけるオキサリプラチン(L-OHP)の血管痛は治療継続の大きな障害となる。そのためわれわれは,看護介入すなわち加温投与ならびに温罨法にてL-OHPによる血管痛の予防効果を介入前後で比較した。2010年1月～2011年1月に,末梢静脈よりL-OHPの投与を受けた患者15名総64コースを評価対象とした。L-OHPは5%ブドウ糖液500 mLに希釈後,2時間で末梢血管より投与した。血管痛と,血管痛のなかでも症状に応じて疼痛と急性の末梢神経障害に分け比較した結果,血管痛の発現率は対照群72.2%に対し介入群56.5%,疼痛の発現率は対照群38.9%に対し介入群32.6%,急性の末梢神経障害の発現率は対照群54.5%に対し介入群25.8%であり,すべての評価項目とも低下を認めた。以上より,加温投与ならびに温罨法は,L-OHPによる軽度の血管痛の症状緩和に有効である可能性が示唆された。
目次
Summary
Venous pain induced by oxaliplatin(L-OHP)is a clinical problem in relation to adherence in the CapeOX regimen. We investigated the preventive effect of nursing care preheating administration of L-OHP a hot compress for colorectal cancer patients who received L-OHP via the peripheral venous route between January 2010 and January 2011. L-OHP was diluted in 500 mL of 5% glucose and administered by 2 hours. We evaluated a total of 64 courses among fifteen patients. The presence of any symptoms, any pain with or without touch, and some symptoms of numbness at the L-OHP-administered arm were defined as phlebitis, venous pain, and acute peripheral neuropathy, respectively. The prevalence of phlebitis, venous pain, and acute peripheral neuropathy in the nursing care group was 56.5%, 32.6%, and 25.8%, respectively, which was not significantly less in comparison with the control group(72.2%, 38.9%, and 54.5%, respectively). These results suggest that both types of nursing care, preheating administration and a hot compress, may be effective for the relief of acute peripheral neuropathy induced by L-OHP.
要旨
実地臨床では,CapeOXにおけるオキサリプラチン(L-OHP)の血管痛は治療継続の大きな障害となる。そのためわれわれは,看護介入すなわち加温投与ならびに温罨法にてL-OHPによる血管痛の予防効果を介入前後で比較した。2010年1月～2011年1月に,末梢静脈よりL-OHPの投与を受けた患者15名総64コースを評価対象とした。L-OHPは5%ブドウ糖液500 mLに希釈後,2時間で末梢血管より投与した。血管痛と,血管痛のなかでも症状に応じて疼痛と急性の末梢神経障害に分け比較した結果,血管痛の発現率は対照群72.2%に対し介入群56.5%,疼痛の発現率は対照群38.9%に対し介入群32.6%,急性の末梢神経障害の発現率は対照群54.5%に対し介入群25.8%であり,すべての評価項目とも低下を認めた。以上より,加温投与ならびに温罨法は,L-OHPによる軽度の血管痛の症状緩和に有効である可能性が示唆された。