内容紹介
Reinforcement of Warfarin Action in a Patient Administered S-1
Summary
A case showing reinforcement of the action of warfarin and potassium in a patient administered S-1 is reported. The patient was a 71-year-old man with left upper gingival cancer. He had ventricular tachycardia(VT), hypertrophic cardiomyopathy, and a cerebellar infarction. He underwent a pacemaker implantation, and was administered warfarin. After the operation, in mid-March 2010, he was administered with S-1 and warfarin. However, the international normalized ratio of prothrombin time(PT-INR)increased to an extremely high level of 5.82, and S-1 and warfarin were stopped. They were re-administered at the end of April, and the PT-INR stabilized to approximately 2.
要旨
口腔癌患者にS-1とワルファリンカリウム製剤(ワルファリン)を併用し,international normalized ratio of prothrombin time(PT-INR)に著明な延長を認めた1例を報告する。症例: 患者は71歳,男性で左上顎歯肉癌患者。既往歴にventricular tachycardia(VT),肥大型心筋症,小脳梗塞があり,implantable cardioverter defibrillator(ICD)植え込み中でワルファリンを内服中であった。術後の2010年3月中旬よりワルファリンとS-1の内服を開始したところ,PT-INR 5.82と著明に延長した。S-1,ワルファリンをいったん中止し,同年4月下旬からS-1,ワルファリンを再開しワルファリンの投与量を調節したところ,PT-INRはおおむね2前後にコントロールされた。
目次
Summary
A case showing reinforcement of the action of warfarin and potassium in a patient administered S-1 is reported. The patient was a 71-year-old man with left upper gingival cancer. He had ventricular tachycardia(VT), hypertrophic cardiomyopathy, and a cerebellar infarction. He underwent a pacemaker implantation, and was administered warfarin. After the operation, in mid-March 2010, he was administered with S-1 and warfarin. However, the international normalized ratio of prothrombin time(PT-INR)increased to an extremely high level of 5.82, and S-1 and warfarin were stopped. They were re-administered at the end of April, and the PT-INR stabilized to approximately 2.
要旨
口腔癌患者にS-1とワルファリンカリウム製剤(ワルファリン)を併用し,international normalized ratio of prothrombin time(PT-INR)に著明な延長を認めた1例を報告する。症例: 患者は71歳,男性で左上顎歯肉癌患者。既往歴にventricular tachycardia(VT),肥大型心筋症,小脳梗塞があり,implantable cardioverter defibrillator(ICD)植え込み中でワルファリンを内服中であった。術後の2010年3月中旬よりワルファリンとS-1の内服を開始したところ,PT-INR 5.82と著明に延長した。S-1,ワルファリンをいったん中止し,同年4月下旬からS-1,ワルファリンを再開しワルファリンの投与量を調節したところ,PT-INRはおおむね2前後にコントロールされた。