内容紹介
A Case of Renal Salt-Wasting Syndrome during Chemotherapy for Advanced Gastric Cancer
Summary
A 66-year-old woman was admitted to our hospital with heartburn and liver dysfunction. She was diagnosed with advanced gastric cancer. After the initiation of chemotherapy with trastuzumab, capecitabine, and cisplatin, she developed hyponatremia and renal failure with renal salt-wasting syndrome(RSWS). She recovered from these conditions after infusion of hypertonic saline. A diagnosis of RSWS should be considered in patients with hyponatremia who receive cisplatin-based chemotherapy.
要旨
症例は66歳,女性。胸やけ,肝機能障害を認め,上部消化管内視鏡検査,CT検査にて進行胃癌,多発肝転移と診断した。シスプラチン(CDDP)を含む化学療法中に嘔気と意識障害が出現し著明な低Na血症を認め,renal salt-wasting syndrome(RSWS)と診断し,水分とNa補充により回復が得られた。CDDP投与中に低Na血症を生じた場合は,まれな病態であるがRSWSも念頭に置き治療を行う必要がある。
目次
Summary
A 66-year-old woman was admitted to our hospital with heartburn and liver dysfunction. She was diagnosed with advanced gastric cancer. After the initiation of chemotherapy with trastuzumab, capecitabine, and cisplatin, she developed hyponatremia and renal failure with renal salt-wasting syndrome(RSWS). She recovered from these conditions after infusion of hypertonic saline. A diagnosis of RSWS should be considered in patients with hyponatremia who receive cisplatin-based chemotherapy.
要旨
症例は66歳,女性。胸やけ,肝機能障害を認め,上部消化管内視鏡検査,CT検査にて進行胃癌,多発肝転移と診断した。シスプラチン(CDDP)を含む化学療法中に嘔気と意識障害が出現し著明な低Na血症を認め,renal salt-wasting syndrome(RSWS)と診断し,水分とNa補充により回復が得られた。CDDP投与中に低Na血症を生じた場合は,まれな病態であるがRSWSも念頭に置き治療を行う必要がある。