内容紹介
Changes in Appetite, Nutrition, and Oxidative Stress Reaction of Cancer Patients during Chemotherapy
Summary
Weight loss during chemotherapy is a result of malnutrition and metabolism abnormality. A few reports have focused on the treatment and prevention of weight and appetite loss in patients with advanced cancer. We evaluated the relationship between weight and appetite loss during chemotherapy by studying the meal intake of patients. In addition, we also investigated whether anorexia is associated with the level of 8-hydroxy-2′-deoxyguanosine(8-OHdG), an oxidation stress marker. The weight loss rate in patients who lack energy intake was significantly higher than that in patients with adequate energy intake. Moreover, the pre-chemotherapy total energy intake, measured according to the hospital meal consumption of patients, was lower among those with than among those without anorexia. The 8-OHdG levels in the patients with anorexia were significantly higher. In conclusion, nutritional management is important for patients even before chemotherapy is started. The 8-OHdG level can be used as an index to evaluate appetite.
要旨
化学療法中がん患者の体重減少の原因は低栄養や代謝異常があり,治療や予防方法に関する研究が進んでいる。今回われわれは,化学療法中のがん患者の体重や食欲変化が食事摂取状況の影響を受けるか調査し,食事指導方法について検討した。加えて,食欲と酸化ストレスマーカーの8-hydroxy-2′-deoxyguanosine(8-OHdG)との関連性を調べ,8-OHdGが食欲評価の指標となり得るか検討した。結果,エネルギー摂取量不足の患者は体重減少率が大きく,化学療法中に食欲が低下した患者は,化学療法開始前からすでにエネルギー摂取量が低かった。8-OHdG値は,食欲のない患者のほうが高く上昇した。したがって,早期から栄養介入を実施することが重要であり,8-OHdG値は食欲評価の指標になり得ることが示唆された。
目次
Summary
Weight loss during chemotherapy is a result of malnutrition and metabolism abnormality. A few reports have focused on the treatment and prevention of weight and appetite loss in patients with advanced cancer. We evaluated the relationship between weight and appetite loss during chemotherapy by studying the meal intake of patients. In addition, we also investigated whether anorexia is associated with the level of 8-hydroxy-2′-deoxyguanosine(8-OHdG), an oxidation stress marker. The weight loss rate in patients who lack energy intake was significantly higher than that in patients with adequate energy intake. Moreover, the pre-chemotherapy total energy intake, measured according to the hospital meal consumption of patients, was lower among those with than among those without anorexia. The 8-OHdG levels in the patients with anorexia were significantly higher. In conclusion, nutritional management is important for patients even before chemotherapy is started. The 8-OHdG level can be used as an index to evaluate appetite.
要旨
化学療法中がん患者の体重減少の原因は低栄養や代謝異常があり,治療や予防方法に関する研究が進んでいる。今回われわれは,化学療法中のがん患者の体重や食欲変化が食事摂取状況の影響を受けるか調査し,食事指導方法について検討した。加えて,食欲と酸化ストレスマーカーの8-hydroxy-2′-deoxyguanosine(8-OHdG)との関連性を調べ,8-OHdGが食欲評価の指標となり得るか検討した。結果,エネルギー摂取量不足の患者は体重減少率が大きく,化学療法中に食欲が低下した患者は,化学療法開始前からすでにエネルギー摂取量が低かった。8-OHdG値は,食欲のない患者のほうが高く上昇した。したがって,早期から栄養介入を実施することが重要であり,8-OHdG値は食欲評価の指標になり得ることが示唆された。