内容紹介
A Case of a Suspected Photosensitive Reaction Induced by Weekly Paclitaxel as Neoadjuvant Chemotherapy for Breast Cancer
Summary
We report a suspected photosensitive reaction induced by weekly paclitaxel(PTX)in a patient with breast cancer. The patient was a 72-year-old woman with right breast cancer(T2N1M0, StageⅡB). She received 80 mg/m2 PTX weekly as neoadjuvant chemotherapy. After the 5 courses of weekly PTX, she began to develop skin lesions with itchy sensations on the areas of her body that had been exposed to sunlight. The symptoms persisted after the 6 courses of weekly PTX, and topical steroid and antihistamine treatments were initiated. The skin lesions resolved once the patient avoided sunlight and used sunscreen. Ultimately, she received 12 courses of PTX. We need to recognize the appearance of a photosensitive reaction following weekly PTX for breast cancer.
要旨
パクリタキセル(PTX)による光線過敏症が疑われた症例を経験したので報告する。症例は72歳,女性。右乳癌(T2N1M0,StageⅡB)にて術前化学療法として毎週PTX(80 mg/m2)が開始された。5コース目の投与後より肌露出部位に騒痒感を伴う紅斑が出現した。6コース目の投与時も症状は持続しており,ステロイド外用剤ならびに抗ヒスタミン剤を開始した。日光曝露を避け,日焼け止めを使用することで症状は軽減し,PTXの投与を12コース実施可能であった。PTX投与においては光線過敏症の発現を認識する必要がある。
目次
Summary
We report a suspected photosensitive reaction induced by weekly paclitaxel(PTX)in a patient with breast cancer. The patient was a 72-year-old woman with right breast cancer(T2N1M0, StageⅡB). She received 80 mg/m2 PTX weekly as neoadjuvant chemotherapy. After the 5 courses of weekly PTX, she began to develop skin lesions with itchy sensations on the areas of her body that had been exposed to sunlight. The symptoms persisted after the 6 courses of weekly PTX, and topical steroid and antihistamine treatments were initiated. The skin lesions resolved once the patient avoided sunlight and used sunscreen. Ultimately, she received 12 courses of PTX. We need to recognize the appearance of a photosensitive reaction following weekly PTX for breast cancer.
要旨
パクリタキセル(PTX)による光線過敏症が疑われた症例を経験したので報告する。症例は72歳,女性。右乳癌(T2N1M0,StageⅡB)にて術前化学療法として毎週PTX(80 mg/m2)が開始された。5コース目の投与後より肌露出部位に騒痒感を伴う紅斑が出現した。6コース目の投与時も症状は持続しており,ステロイド外用剤ならびに抗ヒスタミン剤を開始した。日光曝露を避け,日焼け止めを使用することで症状は軽減し,PTXの投与を12コース実施可能であった。PTX投与においては光線過敏症の発現を認識する必要がある。