内容紹介
New Combination Therapy to Improve the Functional Preservation Rate of the Larynx in Laryngeal, Oropharyngeal, and Hypopharyngeal Cancers
Summary
A new combination therapy has been developed to achieve high overall survival and functional laryngeal preservation rates in head and neck cancers, which require laryngectomy. In order to treat the primary site without resection, superselective intra-arterial infusions with DCF anterogradely and 60 mg/m2 of DOC and 60 mg/m2 of CDDP via the femoral artery on day 1 were administered, followed by continuous intravenous instillation of 750 mg/m2/day of 5-FU for 5 days from day 2. The 5-year survival rate was 70.4% in laryngeal cancer, 72.8% in oropharyngeal cancer, and 68.5% in hypopharyngeal cancer. The 5-year functional laryngeal preservation rate was 71.0% in laryngeal cancer, 63.4% in oropharyngeal cancer, and 65.2% in hypopharyngeal cancer. In addition to regional lymph node control, a thorough neck dissection was performed. Good overall survival and functional laryngeal preservation rates were achieved.
要旨
喉頭全摘出術が必要な頭頸部癌症例において,生存率と機能的喉頭温存率の向上を目的とした治療方法を開発した。原発巣に対しては,DOC 60 mg/m2,CDDP 60 mg/m2の2剤をSeldinger法により動注し,5-FU 750 mg/m2/dayを120時間点滴持続静注する導入化学療法と同時放射線化学療法を施行し,原発巣の制御と機能的喉頭温存を図った。各種癌における5年生存率,5年機能的喉頭温存率は,それぞれ喉頭癌(64例)で70.4%,71.0%,中咽頭癌(51例)で72.8%,63.4%,下咽頭癌(57例)では68.5%,65.2%であった。また,所属リンパ節制御には徹底した頸部郭清術で対応した。その結果,良好な生存率と機能的喉頭温存率を得られた。
目次
Summary
A new combination therapy has been developed to achieve high overall survival and functional laryngeal preservation rates in head and neck cancers, which require laryngectomy. In order to treat the primary site without resection, superselective intra-arterial infusions with DCF anterogradely and 60 mg/m2 of DOC and 60 mg/m2 of CDDP via the femoral artery on day 1 were administered, followed by continuous intravenous instillation of 750 mg/m2/day of 5-FU for 5 days from day 2. The 5-year survival rate was 70.4% in laryngeal cancer, 72.8% in oropharyngeal cancer, and 68.5% in hypopharyngeal cancer. The 5-year functional laryngeal preservation rate was 71.0% in laryngeal cancer, 63.4% in oropharyngeal cancer, and 65.2% in hypopharyngeal cancer. In addition to regional lymph node control, a thorough neck dissection was performed. Good overall survival and functional laryngeal preservation rates were achieved.
要旨
喉頭全摘出術が必要な頭頸部癌症例において,生存率と機能的喉頭温存率の向上を目的とした治療方法を開発した。原発巣に対しては,DOC 60 mg/m2,CDDP 60 mg/m2の2剤をSeldinger法により動注し,5-FU 750 mg/m2/dayを120時間点滴持続静注する導入化学療法と同時放射線化学療法を施行し,原発巣の制御と機能的喉頭温存を図った。各種癌における5年生存率,5年機能的喉頭温存率は,それぞれ喉頭癌(64例)で70.4%,71.0%,中咽頭癌(51例)で72.8%,63.4%,下咽頭癌(57例)では68.5%,65.2%であった。また,所属リンパ節制御には徹底した頸部郭清術で対応した。その結果,良好な生存率と機能的喉頭温存率を得られた。