内容紹介
Local Microwave Hyperthermia for Advanced or Recurrent Breast Cancer
Summary
The purpose of our study was to test the efficacy and toxicity of hyperthermia for treating breast cancer. Ten patients received treatment(AC, paclitaxel, S-1, and aromatase inhibitor)in combination with hyperthermia. The hyperthermia device was a microwave heating device with water loaded and water-cooled waveguides. The temperature was monitored subcutaneously in the skin under the aperture of the waveguide. Two patients had a partial response to treatment with only mild toxicity(grade 1 acute skin toxicity). Therefore, hyperthermia combined with chemotherapy for treating breast cancer seems to be effective and generally tolerable. A larger patient cohort is needed to confirm these results in the future.
要旨
2014年5月～2015年5月まで当院で再発・転移乳がんと診断された10例に対し化学療法(AC療法,パクリタキセル,S-1)もしくはホルモン療法を行い,温熱療法を併用した。結果はPR 2例,SD 5例であった。また,PR 2例のうち1例は経口抗がん剤S-1,もう1例はホルモン剤であった。さらに,がん性胸水やがん性腹水にも劇的に効果がみられた。温熱療法で特に重大な有害事象は認められず,温熱療法に化学療法やホルモン療法の併用は有用である可能性を示唆した。
目次
Summary
The purpose of our study was to test the efficacy and toxicity of hyperthermia for treating breast cancer. Ten patients received treatment(AC, paclitaxel, S-1, and aromatase inhibitor)in combination with hyperthermia. The hyperthermia device was a microwave heating device with water loaded and water-cooled waveguides. The temperature was monitored subcutaneously in the skin under the aperture of the waveguide. Two patients had a partial response to treatment with only mild toxicity(grade 1 acute skin toxicity). Therefore, hyperthermia combined with chemotherapy for treating breast cancer seems to be effective and generally tolerable. A larger patient cohort is needed to confirm these results in the future.
要旨
2014年5月～2015年5月まで当院で再発・転移乳がんと診断された10例に対し化学療法(AC療法,パクリタキセル,S-1)もしくはホルモン療法を行い,温熱療法を併用した。結果はPR 2例,SD 5例であった。また,PR 2例のうち1例は経口抗がん剤S-1,もう1例はホルモン剤であった。さらに,がん性胸水やがん性腹水にも劇的に効果がみられた。温熱療法で特に重大な有害事象は認められず,温熱療法に化学療法やホルモン療法の併用は有用である可能性を示唆した。